Innovation Wing Two

Memristor-based Neuromorphic Computing Systems

Innovation Wing Two, Third exhibition / By

The evolution of artificial intelligence (AI) and the growing demands from Big Data are hampered by current hardware performance, spurring extensive research into accelerator chips. As silicon transistors reach physical limits, there is an urgent need to explore new computing paradigms based on unconventional devices.
Dr Li’s team is developing new brain-inspired computing paradigms using emerging memory devices, aiming to showcase the potential of these neuromorphic computing systems in laboratory settings.

TechTalk – Expanded Potential Stem Cells: A New Tool for Basic and Translational Research

Innovation Wing Two, TechTalk / By

August 3, 2023 (Thursday) 4:30-5:30pm
Mouse embryonic stem cells (ESCs) derived from the epiblast contribute to the somatic lineages and the germline upon reintroduction to the blastocyst but are excluded from the extraembryonic tissues in the placenta that are derived from the trophectoderm (TE) and the primitive endoderm (PrE). By inhibiting signal pathways implicated in the earliest embryo development, we established cultures of mouse expanded potential stem cells (EPSCs) from individual 4-cell and 8-cell blastomeres, by direct conversion of embryonic stem cells (ESCs) and through reprogramming somatic cells. Bona fide trophoblast stem cell (TSC) lines, extra-embryonic endoderm stem (XEN) cells, and ESCs could be directly derived from EPSCs in vitro. The knowledge of mouse EPSCs has enabled the establishment of EPSCs of human, pig, bovine and additional mammalian species. EPSCs of these species share similar molecular features and developmental potentials. They are genetically and epigenetically stable, can be maintained in homogenous long-term cultures and permit efficient precision and complex genome editing. EPSCs thus provide new tools for studying normal development and open up new avenues for translational research in biotechnology, agriculture, and regenerative medicine. For example, we find that early syncytiotrophoblasts produced from human TSCs are highly susceptible to coronavirus infection. This finding has enabled the development of a new stem cell-based antiviral drug discovery technology. I will discuss our thoughts on collaborations with engineering colleagues.

TechTalk – Pandemic Preparedness and Response in the Age of Information

Innovation Wing Two, TechTalk / By

Global responses to the COVID-19 pandemic have largely been suboptimal due to significant underdevelopment of infrastructure, human capital and analytics in pandemic prevention, preparedness, and response (PPR). In particular, epidemic nowcasting has been universally challenging because it requires distilling informative or actionable insights from diverse range of real-world data which are often biased. Misinterpretation, misrepresentation or otherwise misuse of these nowcasts will fuel infodemics, as we have learned to our detriment during the COVID-19 pandemic. We will discuss some lessons learned from COVID-19 and how we can strengthen pandemic PPR in the Age of Information.

TechTalk – Theoretical Concepts and Innovative Laboratory Techniques for Estimating the Effective Permeability of Rocks: Applications to the Longyou Claystone

Innovation Wing Two, TechTalk / By

The Longyou Caves represent an important historical site in China that has undergone periodic water level changes over several centuries. The ground water flow through the intact rock and fractures is an important factor in the geotechnical assessment of the site. The Environmental Geomechanics Laboratory at McGill University has focused on the development of innovative theoretical approaches and experimental facilities for wide range of rocks including Indiana Limestone, the Cobourg Limestone, the Vermont Granite and the Lac du Bonnet Granite, using both steady state and transient techniques. In this Teck Talk, Professor Selvadurai will present a range of experimental techniques, their theoretical interpretations that can be used to estimate of fluid transport processes through intact rocks that can be described by Darcy’s law. The theoretical and experimental techniques are used to determine the intact permeability of Longyou claystone recovered from the site.

TechTalk – Rapid Diagnostic Tests for Emerging Infectious Diseases

Innovation Wing Two, TechTalk / By

Emerging infectious diseases, such as COVID-19 and pandemic influenza, have a significant impact on the healthcare system and the society. Rapid diagnostic tests are essential for guiding patient management and infection control measures, which lead to improvement in patient outcome and prevent outbreaks in the community and in hospitals. In recent years, fully automated testing has greatly reduced the complexity of diagnostic testing and shortened the turn-around time. Despite their potential benefits, several challenges need to be addressed. In this talk, Professor To will present the advances in rapid diagnostic testing, and will discuss about the hurdles in implementing these novel technologies in real-life settings.

TechTalk – Organic Neuromorphic Materials and Devices

Innovation Wing Two, TechTalk / By

By integrating sensing, memory and processing functionalities, biological nervous systems are energy and area efficient. Emulating such capabilities in artificial systems is, however, challenging and is limited by the device heterogeneity of sensing and processing cores., Here, we present a universal solution to simultaneously perform multi-modal sensing, memory and processing using organic electrochemical transistors. The device has a vertical traverse architecture and a crystalline–amorphous channel that can be selectively doped by ions to enable two reconfigurable modes: volatile receptor and non-volatile synapse. As a volatile receptor, the device is capable of multi-modal sensing, and as a non-volatile synapse, it is capable of 10-bit analogue states, low switching stochasticity and good state retention. Homogeneous integration of such devices enables functions such as conditioned reflex and real-time cardiac disease diagnose via reservoir computing, illustrating the promise for future edge AI hardware.

Young Scholar TechTalk – Chip-scale Sensing: From Classical to Quantum Regime

Innovation Wing Two, TechTalk / By

Miniature optoelectronic sensors which have features of convenient, reliable, economic, ultra sensitive, and capable of real-time measurement are highly desirable nowadays. However, currently reported optical and electronic sensing devices are still hindered with complex optical components and bulky equipment. Hence, we hope to further minimize the volume of the sensing system and get rid of the dependence on complex, expensive and bulky sensing components. In particular, we demonstrate a micro-scale III-nitride chip that integrates a light emitter (LED) and a photodetector (PD) together, realizing the emission and detection of signals in a single miniature chip. Thus, we have applied the device into some classical sensing, such as pressure, salinity content and cell activities sensing. Additionally, we also conduct integration on the diamond based quantum sensing system, and demonstrate a compact chip architecture (sub ~mm3 volume) being capable of on-chip quantum sensing.

TechTalk – Biomimetic Soft Materials for Bio-Integrated Smart Devices

Innovation Wing Two, TechTalk / By

Biological tissues are soft, dynamic, and water-rich, while abiotic tools are typically rigid, static, and dry. These differences in physical properties have presented challenges for the development of advanced biomedical systems that require interfacing with the human body. In this presentation, I will introduce our recent work on biomimetic soft composites as a platform for engineering bio-integrated devices that can potentially bridge this gap. These synthetic materials capture important structural features of natural soft tissues and exhibit tissue-mimetic reconfigurability, robustness, and functionality, making them advantageous for constructing bio-interfaces. Soft electronic components were also integrated into the biomimetic materials platform, enabling multifunctional systems for physiological sensing and targeted stimulation. Examples of these smart biomedical tools include artificial cartilage and tendons, electroconductive hydrogels, and organ-integrated 3D electronics, which create exciting opportunities in advanced biomedicine.

TechTalk – A “Programmable” Cell Niche Engineering Platform – Multiphoton Microfabrication and Micropatterning (MMM) Technology

Innovation Wing Two, TechTalk / By

In native tissues, cells reside in a complex microenvironment (niche) consisting of factors including neighbor cells, soluble factors, extracellular matrices, topological and mechanical signals. Cell niche is critical in maintaining their phenotype and determining their fates and functions. Reconstituting complex cell niche factors in vitro, either individually or in combinations, in a quantitatively and spatially controllable manner, is critical for investigating the interactions between cells and their niches and hence deriving designing strategies for optimal conditions during cell culture applications and optimal scaffolds for tissue engineering applications. Our lab has developed a multiphoton microfabrication and micropatterning (MMM) technology. Here, the technical capability of the MMM platform in fabricating complex protein microstructures and micropatterns with pre-designed topological features, mechanical properties, extracellular matrix, cell interaction molecules and soluble factors, and biomedical applications including cell niche factor screening for phenotype maintenance and engineering cell niche for cell fate determination will be discussed.