Biological tissues are soft, dynamic, and water-rich, while abiotic tools are typically rigid, static, and dry. These differences in physical properties have presented challenges for the development of advanced biomedical systems that require interfacing with the human body. In this presentation, I will introduce our recent work on biomimetic soft composites as a platform for engineering bio-integrated devices that can potentially bridge this gap. These synthetic materials capture important structural features of natural soft tissues and exhibit tissue-mimetic reconfigurability, robustness, and functionality, making them advantageous for constructing bio-interfaces. Soft electronic components were also integrated into the biomimetic materials platform, enabling multifunctional systems for physiological sensing and targeted stimulation. Examples of these smart biomedical tools include artificial cartilage and tendons, electroconductive hydrogels, and organ-integrated 3D electronics, which create exciting opportunities in advanced biomedicine.